منابع مشابه
Citrate-mediated iron uptake in Pseudomonas aeruginosa: involvement of the citrate-inducible FecA receptor and the FeoB ferrous iron transporter.
In an attempt to identify components of a ferric citrate uptake system in Pseudomonas aeruginosa, a mutant library of a siderophore-deficient strain (IA614) was constructed and screened for defects in citrate-promoted growth in an Fe-restricted medium. A mutant disrupted in gene PA3901, encoding a homologue of the outer-membrane ferric citrate receptor, FecA, of Escherichia coli (FecA(E.c.)), w...
متن کاملDiscovery of an iron-regulated citrate synthase in Staphylococcus aureus.
Bacteria need to scavenge iron from their environment, and this is no less important for bacterial pathogens while attempting to survive in the mammalian host. One key strategy is the synthesis of small iron chelators known as siderophores. The study of siderophore biosynthesis systems over the past several years has shed light on novel enzymology and, as such, has identified new therapeutic ta...
متن کاملGenetic analysis of iron citrate toxicity in yeast: implications for mammalian iron homeostasis.
Deletion of the yeast homologue of frataxin, YFH1, results in mitochondrial iron accumulation and respiratory deficiency (petite formation). We used a genetic screen to identify mutants that modify iron-associated defects in respiratory activity in Deltayfh1 cells. A deletion in the peroxisomal citrate synthase CIT2 in Deltayfh1 cells decreased the rate of petite formation. Conversely, overexpr...
متن کاملIron transport in Mycobacterium smegmatis: Uptake of iron from ferric citrate.
In mycobacterial growth medium 40 to 400 microM citrate was required to solubilize 2 microM 55Fe. This solubilized 55Fe was taken up into both iron-deficient and iron sufficient washed cell suspensions of Mycobacterium smegmatis and Mycobacterium bovis BCG. Although the 55Fe was taken up into the cell, the citrate was not. The uptake system with M. smegmatis was not inhibited by electron transp...
متن کاملAspergillus niger Secretes Citrate to Increase Iron Bioavailability
Aspergillus niger has an innate ability to secrete various organic acids, including citrate. The conditions required for A. niger citrate overproduction are well described, but the physiological reasons underlying extracellular citrate accumulation are not yet fully understood. One of the less understood culture conditions is the requirement of growth-limiting iron concentrations. While this ha...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1842
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(02)85350-8